After McKenna & Bell, 1997, and de Iuliis, Bargo & Vizcaíno, 2000

<==o †Pampatheriidae Paula Couto, 1954
   |-- †Machlydotherium asperum Ameghino, 1902
   |-- †Kraglievichia paranense (Ameghino, 1883) [Kraglievichia Castellanos, 1937; Plaina Castellanos, 1937]
   |--o †Vassallia Castellanos, 1927
   |  |-- †V. minuta (Moreno & Marcerat, 1891)
   |  `-- †V. maxima Castellanos, 1946
   |?- †Plaina intermedia Castellanos, 1937 [= Vassallia??]
   |-- †Scirrotherium hondaesis
   |--o †Pampatherium Gervais & Ameghino, 1880 [Chlamytherium Lund, in Orsted, 1839; Clamydotherium Lund, 1839; Holmesina Simpson, 1930; Hoffstetteria Castellanos, 1957]
   |  |-- †P. typum (Ameghino, 1875)
   |  `-- †P. humboldtii (Lund, 1839)
   `--o †Holmesina
      |-- †H. occidentalis (Hoffstetter, 1952)
      |-- †H. septentrionalis
      `-- †H. paulacoutoi Cartelle & Bohórquez, 1985

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