Problems with Chandra RK (1992) Lancet 340:1124-7

Effect of vitamin and trace-element supplementation

on immune responses and infection in elderly subjects.

PubMed abstract

Collected by:
Harri Hemilä
Department of Public Health
University of Helsinki, Helsinki, Finland
This file:

Version May 29, 2012

The Chandra 1992 paper in Lancet has been particularly influential in the field of nutrition and infections diseases.
It has been cited over 340 times by July 2009 (Web of Science).

Chandra had been a respected nutritionist, e.g.
Chandra received the McCollum award in 1990
E.V. McCollum Award: Given to a clinical investigator who is perceived currently as a major creative force, actively generating new concepts in nutrition and personally seeing to the execution of studies testing the validity of these concepts. The cash award and inscribed plaque are sponsored by Wyeth Nutrition.
Ranjit Chandra has twice been nominated for the Nobel Prize in medicine.
He is an officer of the Order of Canada, the holder of five honorary doctorates and a visiting professor at universities on four continents.

A summary of the story:

See discussions of the story:

Kondro W, Hebert PC (2007) Research misconduct? What misconduct?

Margetts, Barrie (2006) Stopping the rot in nutrition science.
Public Health Nutrition

Roberts, Seth (2006) Dealing with scientific fraud: a proposal.
Public Health Nutrition

Sterken, Elisabeth (2006) The impact of scientific misconduct on child health
Public Health Nutrition

Sternberg, Saul & Roberts, Seth (2006) Nutritional supplements and infection in the elderly: why do the findings conflict?
Nutr J

Marcovitch, Harvey (2006) Research misconduct: can Australia learn from the UK's stuttering system?

Kouzin J, Unger K (2006) SCIENTIFIC MISCONDUCT: Cleaning Up the Paper Trail

White (2004) Three journals raise doubts on validity of Canadian studies [news].


and… more in BMJ:

The secret life of Dr Chandra

Suspected research fraud: difficulties of getting at the truth

Investigating allegations of scientific misconduct

Investigating the previous studies of a fraudulent author

Validity of Canadian studies: Response of editor of BMJ


Smith (2005) Research misconduct: the poisoning of the well

Shenkin SD (2002) Supplementation and the elderly: dramatic results?

Roberts S (2003) Do nutritional supplements improve cognitive function in the elderly?
...and...  (Nov 23, 2006)

Carpenter K, Roberts S, Sternberg S (2003) Nutrition and immune function: a 1992 report

Meguid M (2005) Retraction [of Chandra's paper]
see also:

Payne (2005) Nutrition retracts 2001 paper: study by Chandra had been questioned since 2003.
The Scientist

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