Department
of Public Health
University of Helsinki,
Finland
harri.hemila@helsinki.fi
https://www.mv.helsinki.fi/home/hemila
Oct 14,
2022
About
89% of the variation in the effect of vitamin
E
supplementation on pneumonia risk for five subgroups of the ATBC
population was true variation in vitamin
E
effect instead of chance variation.
Hemila
H.
6.Vitamin
E and the risk of pneumonia: using the I2-statistic
to quantify
heterogeneity within a controlled trial.
British
Journal of
Nutrition 2016
https://doi.org/10.1017/S0007114516003408
Vitamin
E may decrease the incidence of pneumonia in elderly males by 72% if
they are not smoking
Hemila
H.
5.Vitamin
E administration may decrease the incidence of pneumonia in elderly
males.
Clinical
Interventions in Aging 2016;11:1379-1385
https://doi.org/10.2147/CIA.S114515
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055121
Very
strong evidence that vitamin E effect on pneumonia incidence is
modified by smoking and level of exercise (P = 0.0004)
Vitamin E
increased risk in some people, decreased risk in some other people,
and had no effect in the majority.
Hemila
H, Kaprio J.
4.Subgroup
analysis of large trials can guide further research: a case study of
vitamin E and pneumonia.
Clin Epidemiol
2011;3:51-59
https://doi.org/10.2147/CLEP.S16114
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046185
Different
approach compared with that above.
Restriction
to males who started smoking at early age: pneumonia risk was
increased 14% by vitamin E.
The
increase in risk was restricted to low weight participants (+61%) and
high weight participants (+134%).
Hemila
H, Kaprio J.
3.Vitamin
E
supplementation and pneumonia risk in males who initiated smoking at
an early age: effect modification by body weight and vitamin C.
Nutr J
2008;7:33
https://doi.org/10.1186/1475-2891-7-33
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603040
Vitamin
E halved the incidence of pneumonia in Finnish males who carried out
leisure time exercise.
Hemila
H, Kaprio J, Albanes D, Virtamo J.
2.Physical
activity and pneumonia in male smokers administered vitamin E and
β-carotene.
Int J
Sports Med 2006;27:336-341
https://doi.org/10.1055/s-2005-865670
https://hdl.handle.net/10138/18749
https://www.mv.helsinki.fi/home/hemila/H/2006_IJSM.pdf
Vitamin
E effect on the incidence of pneumonia was significantly modified by
smoking
Hemila
H, Virtamo J, Albanes D, Kaprio J.
1.Vitamin
E and beta-carotene supplementation and hospital-treated pneumonia
incidence in male smokers.
Chest
2004;125:557-565
https://doi.org/10.1378/chest.125.2.557
https://www.mv.helsinki.fi/home/hemila/H/2004_Chest.pdf
Vitamin
E increased TB risk by 125% in people who had high dietary intake of
vitamin C and smoked heavily
Hemila
H, Kaprio J.
Vitamin
E
supplementation may transiently increase tuberculosis risk in males
who smoke heavily and have high dietary vitamin C intake.
Br
J Nutr 2008;100:896-902 [Discussion: 2009;101:145-147]
https://doi.org/10.1017/S0007114508923709
Comments:
https://doi.org/10.1017/S0007114508994411
Reply:
https://doi.org/10.1017/S0007114508994423
Very
strong evidence that the effect of vitamin E on the risk of common
cold depends on age.
Vitamin
E increased or decreased common cold risk in men older than 65
years
Hemila H,
Virtamo J, Albanes D, Kaprio J.
The
effect of vitamin E on common cold incidence is modified by age,
smoking and residential neighborhood.
J
Am Coll Nutr 2006;25:332-339
https://doi.org/10.1080/07315724.2006.10719543
https://helda.helsinki.fi/handle/10138/228095
https://www.mv.helsinki.fi/home/hemila/H/2006_JACN.pdf
Vitamin
E had no substantial effect on common cold risk in males with heavy
job or with heavy leisure time exercises.
Hemila
H, Virtamo J, Albanes D, Kaprio J.
Physical
activity and the common cold in men administered vitamin E and
β-carotene.
MSSE
2003;35:1815-1820
https://doi.org/10.1249/01.MSS.0000093616.60899.92
https://hdl.handle.net/10138/18380
Dietary
vitamin E intake did not correlate with the common cold
incidence
Hemila
H, Kaprio J, Albanes D, Heinonen OP, Virtamo J.
Vitamin
C, vitamin E and beta-carotene in relation to common cold incidence
in male smokers.
Epidemiology
2002;13:32-37
Vitamins
C and E and zinc lozenges and the common cold
Hemila
H. Vitamins
and minerals
[book chapter].
In: "Common
cold"
(Eccles R, Weber
O, eds.) Birkhauser Verlag, 2009:275-307
Abstract
and references:
https://www.mv.helsinki.fi/home/hemila/birkhauser
Available at:
https://doi.org/10.1007/978-3-7643-9912-2_13
Hemila
H.
Spectacular
reduction in the mortality of acutely injured patients by the
administration of vitamins C and E and selenium.
JPEN 2009;33:447-448
https://doi.org/10.1177/0148607108328520
https://www.mv.helsinki.fi/home/hemila/H/2009_L_JPEN.pdf
https://hdl.handle.net/10138/16985
Hemila H.
Evidence-based
medicine and the role of antioxidants in physically-stressed people.
Nutr Rev
2009;67:61-63
https://doi.org/10.1111/j.1753-4887.2008.00134.x
https://www.mv.helsinki.fi/home/hemila/H/2009_L_NutRev.pdf
https://helda.helsinki.fi/handle/10138/228068
Hemila
H.
Vitamin
E supplementation and respiratory infections in the elderly.
JAGS
2007;55:1311-1313
https://doi.org/10.1111/j.1532-5415.2007.01263.x
https://helda.helsinki.fi/handle/10138/225894
https://www.mv.helsinki.fi/home/hemila/H/2007_L_JAGS.pdf
Hemila
H.
Conclusions
about intervention effects should not be based on surrogate end
points.
FRBM
2007;42:578
https://doi.org/10.1016/j.freeradbiomed.2006.11.035
https://hdl.handle.net/10250/8081
https://www.mv.helsinki.fi/home/hemila/H/2007_L_FRBM.pdf
Hemila
H
The
effect of nutrition on exercise-induced immunodepression
Nutrition
Reviews
2006;64:476-477
https://doi.org/10.1111/j.1753-4887.2006.tb00179.x
https://www.mv.helsinki.fi/home/hemila/H/2006_L_NutRev.pdf
Hemila
H.
Potential
harm of vitamin E supplementation.
AJCN 2005;82:1141-1142
https://www.ajcn.org/cgi/content/full/82/5/1141-a
https://www.mv.helsinki.fi/home/hemila/H/2005_L_AJCN.pdf
Hemila
H, Kaprio J.
Vitamin
E and respiratory tract infections in elderly persons.
JAMA 2004;292:2834
https://doi.org/10.1001/jama.292.23.2834-a
https://www.mv.helsinki.fi/home/hemila/H/2004_L_JAMA.pdf