Department of Public Health
University of
Helsinki,
Finland
harri.hemila@helsinki.fi
http://www.mv.helsinki.fi/home/hemila
Feb 24, 2020
Three controlled trials have found
significant decrease in the incidence of pneumonia and two found
treatment benefit for pneumonia patients.
Hemilä H,
Louhiala P.
Vitamin C for preventing and treating pneumonia.
Cochrane Database Syst Rev 2013;
CD005532
http://dx.doi.org/10.1002/14651858.CD005532.pub3
https://helda.helsinki.fi/handle/10138/225862
http://www.mv.helsinki.fi/home/hemila/CP/2013_Coch_Pneu_CD005532.pdf
http://www.ncbi.nlm.nih.gov/pubmed/23925826
A
short review
Hemilä H, Louhiala P.
Vitamin
C may affect lung infections.
JRSM 2007;100:495-498
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2099400
https://doi.org/10.1177/014107680710001109
Hemilä H.
Vitamin C intake and
susceptibility to pneumonia.
Pediatr Infect Dis J
1997;16:836-837
http://dx.doi.org/10.1097/00006454-199709000-00003
https://helda.helsinki.fi/handle/10138/225875
http://www.ncbi.nlm.nih.gov/pubmed/9306475
Hemilä
H.
Vitamin C supplementation and respiratory infections: a
systematic review.
Military Medicine 2004;169:920-925
https://doi.org/10.7205/MILMED.169.11.920
https://helda.helsinki.fi/handle/10138/225867
http://www.mv.helsinki.fi/home/hemila/H/HH_2004.pdf
http://www.ncbi.nlm.nih.gov/pubmed/15605943
Hemilä
H, Douglas RM.
Vitamin C and acute respiratory infections.
Int J TB Lung Dis
1999;3:756-761
http://www.ingentaconnect.com/content/iuatld/ijtld/1999/00000003/00000009/art00004
http://www.mv.helsinki.fi/home/hemila/H/HH_1999_IJTLD.pdf
http://www.ncbi.nlm.nih.gov/pubmed/10488881
Modification
of vitamin E effect by vitamin C also means that vitamin C influences
pneumonia risk.
Hemilä H, Kaprio J.
Vitamin
E supplementation and pneumonia risk in males who initiated smoking
at an early age: effect modification by body weight and vitamin
C. Nutr J
2008;7:33
http://dx.doi.org/10.1186/1475-2891-7-33
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603040
http://www.ncbi.nlm.nih.gov/pubmed/19019244
Comment:
Hemilä
H. Vitamin C and Community-acquired Pneumonia.
AJRCCM
2011;184:621-2.
http://dx.doi.org/10.1164/ajrccm.184.5.621a
Modification of vitamin E effect by
vitamin C also means that vitamin C influences TB risk.
Furthermore,
high dietary vitamin C intake was associated with 60% lower TB risk
in the participants who were not administered vitamin E.
Hemilä
H, Kaprio J.
Vitamin E supplementation may transiently
increase tuberculosis risk in males who smoke heavily and have high
dietary vitamin C intake. Br J Nutr
2008;100:896-902
http://dx.doi.org/10.1017/S0007114508923709
http://www.ncbi.nlm.nih.gov/pubmed/18279551
Discussion: BJN 2009;101:145-147
Comment:
http://dx.doi.org/10.1017/S0007114508994411
Reply:
http://dx.doi.org/10.1017/S0007114508994423
Hemilä
H, Kaprio J, Pietinen P, Albanes D, Heinonen OP.
Vitamin C
and other compounds in vitamin C rich food in relation to risk of
tuberculosis in male smokers.
Am J Epidemiol
1999;150:632-641
http://dx.doi.org/10.1093/oxfordjournals.aje.a010062
http://www.ncbi.nlm.nih.gov/pubmed/10490003
One study in Bangladesh found significant
benefit of vitamin C for tetanus patients, see analysis in:
Hemilä
H, Koivula TT
Vitamin C for preventing and treating tetanus.
Cochrane Database Syst Rev 2013;
CD006665
http://dx.doi.org/10.1002/14651858.CD006665.pub3
https://helda.helsinki.fi/handle/10138/225863
http://www.mv.helsinki.fi/home/hemila/CT/2013_Coch_Tetanus_CD006665.pdf
http://www.ncbi.nlm.nih.gov/pubmed/24226506
References
to the review:
http://www.mv.helsinki.fi/home/hemila/CT
Hemilä
H. Vitamin C and tetanus. Annals of African Medicine
2010;9:108-109
http://www.annalsafrmed.org/text.asp?2010/9/2/108/64742
https://doi.org/10.4103/1596-3519.64742
Hemilä H. Infections in animals.
In: Do vitamins C
and E affect respiratory infections? Thesis 2006 pp.
7-9
http://hdl.handle.net/10138/20335
http://www.mv.helsinki.fi/home/hemila/animals
Hemilä H.
Vitamin
C and infections
Nutrients
2017;9(4):339.
https://doi.org/10.3390/nu9040339
Hemilä H.
Vitamin C and rabies. PLoS
Neglected Tropical Diseases
2011
http://www.plosntds.org/annotation/listThread.action?root=6307
Hemilä
H.
Vitamin C and SARS coronavirus.
JAC
2003;52:1049-1050
http://dx.doi.org/10.1093/jac/dkh002
https://www.mv.helsinki.fi/home/hemila/H/2003_L_JAC
Hemilä
H.
Randomised trials on vitamin C.
Br J Nutr
2011;105:485-487
http://dx.doi.org/10.1017/S000711451000351X
Hemilä
H.
Spectacular reduction in the mortality of acutely injured
patients by the administration of vitamins C and E and selenium.
JPEN 2009;33:447-448
http://dx.doi.org/10.1177/0148607108328520
http://hdl.handle.net/10138/16985
Hemilä H.
The protective effect of vitamins A
and C on endotoxin-induced oxidative renal tissue damage in rats.
Tohoku J Exp Med
2006;208:99-100
http://dx.doi.org/10.1620/tjem.208.99