Problems with Chandra RK (1992) Lancet 340:1124-7

Effect of vitamin and trace-element supplementation

on immune responses and infection in elderly subjects.

http://dx.doi.org/10.1016/0140-6736(92)93151-C

PubMed abstract

Collected by:
Harri Hemilä
Department of Public Health
University of Helsinki, Helsinki, Finland
harri.hemila@helsinki.fi
Home:  http://www.mv.helsinki.fi/home/hemila
This file: http://www.mv.helsinki.fi/home/hemila/birkhauser/chandra.htm

Version May 29, 2012

The Chandra 1992 paper in Lancet has been particularly influential in the field of nutrition and infections diseases.
It has been cited over 340 times by July 2009 (Web of Science).


Chandra had been a respected nutritionist, e.g.
Chandra received the McCollum award in 1990
http://www.nutrition.org/about-asn/awards/past-recipients
E.V. McCollum Award: Given to a clinical investigator who is perceived currently as a major creative force, actively generating new concepts in nutrition and personally seeing to the execution of studies testing the validity of these concepts. The cash award and inscribed plaque are sponsored by Wyeth Nutrition.
 
Ranjit Chandra has twice been nominated for the Nobel Prize in medicine.
He is an officer of the Order of Canada, the holder of five honorary doctorates and a visiting professor at universities on four continents.
http://www.thecanadianencyclopedia.com/index.cfm?PgNm=TCE&Params=M1ARTM0010546



A summary of the story:
http://en.wikipedia.org/wiki/Ranjit_Chandra


See discussions of the story:

Kondro W, Hebert PC (2007) Research misconduct? What misconduct?
CMAJ
http://www.cmaj.ca/cgi/content/full/176/7/905


Margetts, Barrie (2006) Stopping the rot in nutrition science.
Public Health Nutrition
http://dx.doi.org/10.1079/PHN2006947

Roberts, Seth (2006) Dealing with scientific fraud: a proposal.
Public Health Nutrition
http://dx.doi.org/10.1079/PHN2006963

Sterken, Elisabeth (2006) The impact of scientific misconduct on child health
Public Health Nutrition
http://dx.doi.org/10.1079/PHN2006951

Sternberg, Saul & Roberts, Seth (2006) Nutritional supplements and infection in the elderly: why do the findings conflict?
Nutr J
http://www.nutritionj.com/content/5/1/30

Marcovitch, Harvey (2006) Research misconduct: can Australia learn from the UK's stuttering system?
MJA
https://www.mja.com.au/public/issues/185_11_041206/mar11049_fm.html

Kouzin J, Unger K (2006) SCIENTIFIC MISCONDUCT: Cleaning Up the Paper Trail
Science
http://www.sciencemag.org/cgi/content/summary/312/5770/38


BMJ:
White (2004) Three journals raise doubts on validity of Canadian studies [news].
http://dx.doi.org/10.1136/bmj.328.7431.67

correction: http://www.bmj.com/cgi/content/full/328/7434/257
e-letters: http://bmj.bmjjournals.com/cgi/eletters/328/7431/67

and… more in BMJ:

The secret life of Dr Chandra
http://www.bmj.com/cgi/content/full/332/7537/369

Suspected research fraud: difficulties of getting at the truth
http://www.bmj.com/cgi/content/extract/331/7511/281

Investigating allegations of scientific misconduct
http://www.bmj.com/cgi/content/extract/331/7511/245

Investigating the previous studies of a fraudulent author
http://www.bmj.com/cgi/content/extract/331/7511/288

Validity of Canadian studies: Response of editor of BMJ
http://www.bmj.com/cgi/content/full/328/7437/465-b

***

Smith (2005) Research misconduct: the poisoning of the well
JRSM
http://www.jrsm.org/cgi/content/full/99/5/232

Shenkin SD (2002) Supplementation and the elderly: dramatic results?
Nutrition
http://dx.doi.org/10.1016/S0899-9007(02)00768-2

Roberts S (2003) Do nutritional supplements improve cognitive function in the elderly?
Nutrition
http://dx.doi.org/10.1016/S0899-9007(03)00025-X
...and...
http://www.psych.upenn.edu/~saul/critiquetext.pdf
http://www.blog.sethroberts.net/2006/11/  (Nov 23, 2006)
http://sethroberts.net/chandra/index.html
http://sethroberts.net/chandra/2006-02-27_Dealing_with_scientific_fraud-A_proposal.pdf

Carpenter K, Roberts S, Sternberg S (2003) Nutrition and immune function: a 1992 report
Lancet
http://dx.doi.org/10.1016/S0140-6736(03)13755-5

Meguid M (2005) Retraction [of Chandra's paper]
Nutrition
http://dx.doi.org/10.1016/j.nut.2004.12.002
http://www.ncbi.nlm.nih.gov/pubmed/15793927
see also: http://dx.doi.org/10.1016/S0899-9007(03)00023-6

*****
Payne (2005) Nutrition retracts 2001 paper: study by Chandra had been questioned since 2003.
The Scientist
http://www.the-scientist.com/news/20050303/02/printerfriendly
http://www.the-scientist.com/article/display/22614/
http://www.the-scientist.com/news/display/50214/
http://www.thescientist.com/news/display/52921/

http://www.sciencemag.org/cgi/content/summary/303/5657/465b

http://www.cbc.ca/canada/newfoundland-labrador/story/2007/01/23/chandra-review.html?ref=rss
http://www.cbc.ca/canada/newfoundland-labrador/story/2005/03/02/nf-chandra-retraction-20050302.html
http://www.cbc.ca/health/story/2004/06/10/chandra040610.html

http://www.medbroadcast.com/channel_health_news_details.asp?news_id=7452&rss=67&rid=999999&channel_id=1039&rot=3

http://www.canada.com/nationalpost/news/bodyandhealth/story.html?id=47843098-745d-479d-91b4-6615b7f98585

The MUSE:
Memorial's Student Newspaper
http://www.themuse.ca/view.php?aid=39948
http://www.themuse.ca/view.php?aid=39320
http://www.themuse.ca/view.php?aid=38810
http://www.themuse.ca/view.php?aid=38531
http://www.themuse.ca/view.php?aid=38530
http://www.themuse.ca/view.php?aid=38529
http://www.themuse.ca/view.php?aid=38510
http://www.themuse.ca/view.php?aid=38488

http://www.med.mun.ca/munmed/181/pg6_181.htm

https://www.infactcanada.ca/Chandra_Feb72006.htm
https://www.infactcanada.ca/Winter_2006_Pg_1_2.htm
https://www.infactcanada.ca/Chandra_Jan30_2006.htm

http://www.rediff.com/us/2000/may/04us3.htm

http://www.thefactsaboutfitness.com/news/research.htm


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