Index_SNP A12 Frq_case Frq_control Chr Start_Position End_Position Combined_OR Combined_95lower Combined_95upper Combined_P Discovery_OR Discovery_P Replication_OR Replication_P rs4648845 TC 0.533 0.527 1 2372401 2402501 1.072 1.049 1.097 8.7e-10 1.071 4.03e-9 1.088 8.85e-2 chr1_8424984_D I2D 0.319 0.301 1 8411184 8638984 1.071 1.048 1.095 1.17e-9 1.071 2.03e-9 1.057 2.96e-1 rs1498232 TC 0.311 0.296 1 30412551 30437271 1.069 1.046 1.093 2.86e-9 1.072 1.28e-9 0.999 9.88e-1 rs11210892 AG 0.659 0.677 1 44029384 44128084 0.934 0.914 0.954 3.39e-10 0.933 4.97e-10 0.949 3.08e-1 rs12129573 AC 0.377 0.358 1 73766426 73991366 1.078 1.056 1.101 2.03e-12 1.072 2.35e-10 1.217 6.25e-5 rs76869799 CG 0.959 0.964 1 97792625 97834525 0.846 0.798 0.897 2.64e-8 0.850 1.44e-7 0.779 5.34e-2 rs1702294 TC 0.175 0.191 1 98374984 98559084 0.887 0.865 0.911 3.36e-19 0.891 2.79e-17 0.831 1.35e-3 rs140505938 TC 0.151 0.164 1 149998890 150242490 0.914 0.888 0.940 4.49e-10 0.913 9.34e-10 0.928 2.53e-1 rs6670165 TC 0.196 0.184 1 177247821 177300821 1.075 1.047 1.103 4.45e-8 1.074 1.16e-7 1.090 1.46e-1 rs7523273 AG 0.695 0.685 1 207912183 208024083 1.063 1.040 1.087 4.47e-8 1.062 1.61e-7 1.092 8.85e-2 rs10803138 AG 0.232 0.238 1 243503719 243612019 0.933 0.911 0.956 2.03e-8 0.932 1.79e-8 0.968 5.56e-1 rs77149735 AG 0.0225 0.0191 1 243555105 243555105 1.317 1.202 1.444 3.73e-9 1.329 4.4e-9 1.173 3.66e-1 rs14403 TC 0.207 0.222 1 243639893 243664923 0.934 0.911 0.957 4.42e-8 0.935 1.31e-7 0.920 1.53e-1 chr1_243881945_I I2D 0.638 0.619 1 243690945 244002945 1.068 1.045 1.092 6.53e-9 1.066 3.11e-8 1.107 6.17e-2 rs11682175 TC 0.52 0.542 2 57943593 58065893 0.933 0.914 0.952 1.47e-11 0.928 2.54e-12 1.018 7.08e-1 rs75575209 AT 0.904 0.913 2 58025192 58502192 0.902 0.869 0.936 3.95e-8 0.896 1.01e-8 1.056 5.6e-1 rs3768644 AG 0.0967 0.101 2 72357335 72368185 0.904 0.874 0.935 7.39e-9 0.910 1.3e-7 0.765 2.15e-3 chr2_146436222_I I2D 0.176 0.163 2 146416922 146441832 1.086 1.057 1.116 1.81e-9 1.084 1.07e-8 1.128 5.72e-2 chr2_149429178_D I2D 0.955 0.961 2 149390778 149520178 0.857 0.813 0.904 1.59e-8 0.856 2.62e-8 0.880 2.97e-1 rs2909457 AG 0.568 0.593 2 162798555 162910255 0.944 0.925 0.964 4.62e-8 0.943 4.38e-8 0.971 5.36e-1 rs11693094 TC 0.44 0.458 2 185601420 185785420 0.929 0.910 0.948 1.53e-12 0.929 7.13e-12 0.918 7.64e-2 rs59979824 AC 0.322 0.337 2 193848340 194028340 0.937 0.916 0.958 8.41e-9 0.936 1.08e-8 0.959 4.32e-1 rs6434928 AG 0.635 0.643 2 198148577 198835577 0.929 0.909 0.949 2.06e-11 0.927 1.48e-11 0.969 5.36e-1 rs6704641 AG 0.819 0.805 2 200161422 200309252 1.081 1.053 1.110 8.33e-9 1.079 3.4e-8 1.123 8.1e-2 chr2_200825237_I I2D 0.741 0.754 2 200715237 200848037 0.909 0.887 0.932 5.65e-14 0.906 1.78e-14 1.011 8.7e-1 rs11685299 AC 0.313 0.326 2 225334096 225467796 0.939 0.919 0.959 1.12e-8 0.937 1.11e-8 0.974 6.12e-1 rs6704768 AG 0.54 0.552 2 233559301 233753501 0.930 0.911 0.949 2.32e-12 0.929 3.15e-12 0.953 3.19e-1 rs17194490 TG 0.169 0.156 3 2532786 2561686 1.101 1.070 1.132 2.69e-11 1.102 4.87e-11 1.080 2.31e-1 rs4330281 TC 0.479 0.48 3 17221366 17888266 0.940 0.921 0.960 4.64e-9 0.943 5.51e-8 0.890 1.44e-2 rs75968099 TC 0.346 0.324 3 36843183 36945783 1.085 1.062 1.109 1.05e-13 1.082 3.39e-12 1.152 5.05e-3 rs2535627 TC 0.545 0.529 3 52541105 52903405 1.071 1.049 1.092 4.26e-11 1.073 3.96e-11 1.029 5.41e-1 rs832187 TC 0.607 0.615 3 63792650 64004050 0.941 0.922 0.961 1.43e-8 0.941 2.58e-8 0.948 2.82e-1 rs7432375 AG 0.421 0.449 3 135807405 136615405 0.933 0.914 0.953 7.26e-11 0.931 5.27e-11 0.973 5.76e-1 chr3_180594593_I I2D 0.196 0.208 3 180588843 180954593 0.914 0.890 0.938 1.3e-11 0.914 5.35e-11 0.904 9.54e-2 rs9841616 AT 0.158 0.167 3 181023585 181205585 0.925 0.900 0.951 2.35e-8 0.922 1.65e-8 0.978 7.28e-1 rs215411 AT 0.331 0.314 4 23366403 23443403 1.064 1.041 1.087 3.06e-8 1.067 1.22e-8 0.998 9.68e-1 rs35518360 AT 0.909 0.922 4 103146888 103198090 0.857 0.824 0.891 7.98e-15 0.865 9.56e-13 0.662 6.61e-5 rs10520163 TC 0.493 0.47 4 170357552 170646052 1.065 1.043 1.086 1.47e-9 1.063 1.02e-8 1.100 4.33e-2 rs1106568 AG 0.747 0.761 4 176851001 176875801 0.934 0.912 0.956 9.47e-9 0.933 1.15e-8 0.953 3.95e-1 rs1501357 TC 0.794 0.802 5 45291475 45393775 0.926 0.903 0.950 5.05e-9 0.926 1.24e-8 0.924 2.09e-1 rs4391122 AG 0.505 0.532 5 60499143 60843543 0.922 0.904 0.941 1.1e-14 0.924 1.73e-13 0.889 1.46e-2 rs16867576 AG 0.889 0.883 5 88581331 88854331 1.101 1.066 1.138 4.61e-9 1.101 1.36e-8 1.118 1.33e-1 rs4388249 TC 0.212 0.213 5 109030036 109209066 1.076 1.048 1.104 3.05e-8 1.075 1.03e-7 1.098 1.26e-1 rs10043984 TC 0.266 0.252 5 137598121 137750021 1.069 1.045 1.094 1.09e-8 1.069 2.18e-8 1.069 2.36e-1 rs3849046 TC 0.542 0.523 5 137838092 137948092 1.063 1.042 1.085 4.67e-9 1.065 4.83e-9 1.031 5.22e-1 chr5_140143664_I I12D 0.486 0.475 5 140023664 140222664 1.058 1.036 1.079 4.85e-8 1.055 3.6e-7 1.114 2.5e-2 rs79212538 TG 0.0512 0.046 5 151941104 152495104 1.155 1.100 1.213 7e-9 1.152 3.84e-8 1.214 5.77e-2 rs111294930 AG 0.788 0.782 5 152097521 152323121 1.094 1.064 1.124 1.06e-10 1.091 1.31e-9 1.147 1.92e-2 rs2973155 TC 0.353 0.373 5 152505619 152711619 0.933 0.913 0.953 1.11e-10 0.935 1.02e-9 0.892 2.55e-2 rs12522290 CG 0.84 0.83 5 152795306 152797656 1.084 1.054 1.115 1.99e-8 1.086 2.23e-8 1.051 4.6e-1 rs11740474 AT 0.601 0.621 5 153671057 153688217 0.942 0.922 0.962 3.15e-8 0.941 3.94e-8 0.964 4.51e-1 rs115329265 AG 0.864 0.85 6 28303247 28712247 1.205 1.168 1.244 3.48e-31 1.213 3.86e-32 1.037 6.44e-1 rs1339227 TC 0.347 0.368 6 73132701 73171901 0.942 0.922 0.962 2.69e-8 0.942 6.86e-8 0.936 1.78e-1 chr6_84280274_D I2D 0.524 0.505 6 84279922 84407274 1.068 1.046 1.091 8.15e-10 1.070 8.57e-10 1.040 4.6e-1 rs117074560 TC 0.0418 0.0476 6 96459651 96459651 0.849 0.805 0.896 1.64e-9 0.855 1.66e-8 0.730 1.61e-2 chr7_2025096_I DI3 0.405 0.423 7 1896096 2190096 0.922 0.903 0.941 8.2e-15 0.923 6.12e-14 0.911 5.76e-2 chr7_24747494_D DI3 0.104 0.0959 7 24619494 24832094 1.101 1.064 1.139 2.85e-8 1.095 3.59e-7 1.198 1.15e-2 rs12704290 AG 0.111 0.123 7 86403226 86459326 0.904 0.876 0.933 3.33e-10 0.899 1.04e-10 1.007 9.28e-1 rs6466055 AC 0.35 0.332 7 104598064 105063064 1.068 1.046 1.091 1.13e-9 1.068 2.46e-9 1.065 2.01e-1 rs211829 TC 0.641 0.628 7 110034393 110106693 1.061 1.039 1.083 3.71e-8 1.057 5.47e-7 1.154 4.33e-3 rs13240464 TC 0.667 0.647 7 110843815 111205915 1.083 1.060 1.106 3.03e-13 1.084 6.16e-13 1.065 2.19e-1 rs7801375 AG 0.146 0.152 7 131539263 131567263 0.924 0.898 0.951 4.42e-8 0.920 2.26e-8 0.998 9.73e-1 rs3735025 TC 0.657 0.642 7 137039644 137085244 1.066 1.043 1.089 3.28e-9 1.066 7.75e-9 1.065 2.24e-1 rs10503253 AC 0.223 0.219 8 4177794 4192544 1.073 1.048 1.100 1.06e-8 1.073 2.69e-8 1.075 2.11e-1 rs73229090 AC 0.107 0.116 8 27412627 27453627 0.908 0.877 0.939 2.1e-8 0.905 1.95e-8 0.958 5.91e-1 rs6984242 AG 0.586 0.6 8 60475469 60954469 0.941 0.922 0.961 5.97e-9 0.938 1.76e-9 1.015 7.66e-1 rs7819570 TG 0.187 0.174 8 89340626 89753626 1.079 1.051 1.108 1.22e-8 1.080 1.9e-8 1.059 3.46e-1 rs36068923 AG 0.787 0.803 8 111460061 111630761 0.919 0.896 0.942 2.61e-11 0.919 1.05e-10 0.908 9.79e-2 rs4129585 AC 0.447 0.424 8 143309503 143330533 1.087 1.065 1.109 1.74e-15 1.082 2.03e-13 1.194 2.12e-4 rs11139497 AT 0.346 0.337 9 84630941 84813641 1.069 1.045 1.093 3.61e-9 1.070 3.09e-9 1.031 5.76e-1 rs7893279 TG 0.899 0.889 10 18681005 18770105 1.125 1.088 1.162 1.97e-12 1.120 3.56e-11 1.231 7.32e-3 rs7907645 TG 0.9 0.888 10 104423800 104423800 1.143 1.099 1.188 1.27e-11 1.141 5.82e-11 1.185 8.59e-2 rs11191419 AT 0.337 0.36 10 104585135 104956335 0.906 0.886 0.926 6.2e-19 0.907 9.24e-18 0.891 2.23e-2 rs55833108 TG 0.208 0.196 10 104587583 105165583 1.075 1.048 1.103 2.23e-8 1.078 1.42e-8 1.015 8.02e-1 chr10_104957618_I I2D 0.0654 0.0756 10 104957618 104957618 0.843 0.806 0.882 1.06e-13 0.842 1.04e-13 0.911 5.45e-1 rs11027857 AG 0.515 0.499 11 24367320 24412990 1.064 1.042 1.085 2.55e-9 1.065 3.21e-9 1.043 3.74e-1 chr11_46350213_D I2D 0.835 0.85 11 46342943 46751213 0.906 0.881 0.932 1.26e-11 0.905 1.97e-11 0.934 3.06e-1 rs9420 AG 0.327 0.311 11 57386294 57682294 1.068 1.045 1.092 2.24e-9 1.063 6.65e-8 1.187 9.36e-4 rs12421382 TC 0.318 0.334 11 109285471 109610071 0.941 0.921 0.962 3.7e-8 0.943 1.72e-7 0.911 6.57e-2 rs2514218 TC 0.31 0.314 11 113317794 113423994 0.927 0.907 0.948 2.75e-11 0.930 4.09e-10 0.875 8.19e-3 rs77502336 CG 0.337 0.322 11 123394636 123395986 1.066 1.043 1.090 7.54e-9 1.071 2.01e-9 0.982 7.22e-1 rs55661361 AG 0.319 0.335 11 124610007 124620147 0.926 0.906 0.946 2.8e-12 0.925 3.68e-12 0.950 3.31e-1 rs10791097 TG 0.479 0.46 11 130714610 130749330 1.076 1.055 1.098 1.09e-12 1.077 2.88e-12 1.071 1.49e-1 rs75059851 AG 0.812 0.797 11 133808069 133852969 1.091 1.063 1.119 3.87e-11 1.096 1.23e-11 0.995 9.33e-1 rs2007044 AG 0.602 0.624 12 2321860 2413760 0.912 0.894 0.931 3.22e-18 0.912 2.63e-17 0.910 5.07e-2 rs2239063 AC 0.729 0.714 12 2474631 2523731 1.067 1.043 1.091 1.93e-8 1.071 5.39e-9 0.972 6.17e-1 rs679087 AC 0.324 0.337 12 29905265 29940365 0.941 0.921 0.962 3.91e-8 0.941 7.06e-8 0.951 3.17e-1 rs324017 AC 0.293 0.309 12 57428314 57490104 0.938 0.917 0.959 2.13e-8 0.941 2.13e-7 0.877 1.52e-2 rs12826178 TG 0.0627 0.0708 12 57569471 57682971 0.846 0.808 0.887 2.02e-12 0.846 5.3e-12 0.862 1.71e-1 rs4240748 CG 0.358 0.366 12 92243186 92258286 0.943 0.923 0.963 4.59e-8 0.943 1.03e-7 0.941 2.16e-1 rs10860964 TC 0.65 0.646 12 103559855 103616655 1.060 1.038 1.083 4.84e-8 1.061 9.92e-8 1.056 2.71e-1 rs4766428 TC 0.481 0.474 12 110723245 110723245 1.068 1.045 1.091 1.4e-9 1.071 7.09e-10 1.009 8.62e-1 rs2851447 CG 0.723 0.741 12 123448113 123909113 0.915 0.894 0.936 1.86e-14 0.913 2.19e-14 0.953 3.67e-1 rs2068012 TC 0.76 0.771 14 30189985 30190316 0.933 0.910 0.955 1.41e-8 0.933 4.14e-8 0.919 1.32e-1 rs2332700 CG 0.262 0.249 14 72417326 72450526 1.073 1.048 1.098 4.86e-9 1.076 1.69e-9 0.988 8.38e-1 rs2693698 AG 0.412 0.418 14 99707919 99719219 0.939 0.919 0.959 4.8e-9 0.939 1.38e-8 0.933 1.51e-1 rs12887734 TG 0.299 0.287 14 103996234 104184834 1.088 1.064 1.113 1.36e-13 1.091 1.17e-13 1.033 5.3e-1 rs56205728 AG 0.291 0.274 15 40566759 40602237 1.074 1.048 1.099 4.18e-9 1.070 4.92e-8 1.142 1.25e-2 rs12903146 AG 0.544 0.52 15 61831663 61909663 1.067 1.046 1.089 3.38e-10 1.067 1.04e-9 1.078 1.47e-1 rs12148337 TC 0.478 0.465 15 70573672 70628872 1.060 1.038 1.081 1.79e-8 1.059 5.33e-8 1.068 1.73e-1 rs8042374 AG 0.75 0.725 15 78803032 78926732 1.093 1.067 1.119 2.44e-13 1.091 1.87e-12 1.117 4.57e-2 rs190065944 AG 0.274 0.26 15 78859610 78859610 1.078 1.049 1.107 4.71e-8 1.078 7.22e-8 1.074 4.22e-1 rs950169 TC 0.247 0.257 15 84661161 85153461 0.923 0.902 0.945 1.62e-11 0.924 7.62e-11 0.906 6.64e-2 rs4702 AG 0.547 0.562 15 91416560 91429040 0.922 0.902 0.942 8.3e-14 0.925 2.3e-12 0.872 4.3e-3 rs9922678 AG 0.299 0.281 16 9875519 9970219 1.067 1.043 1.091 1.28e-8 1.070 6.72e-9 1.005 9.31e-1 rs7405404 TC 0.238 0.223 16 13728459 13761359 1.077 1.052 1.103 1.01e-9 1.081 3.93e-10 0.999 9.81e-1 rs12691307 AG 0.524 0.51 16 29924377 30144877 1.073 1.051 1.096 4.55e-11 1.073 1.3e-10 1.074 1.41e-1 rs12325245 AT 0.849 0.859 16 58669293 58682833 0.920 0.893 0.947 1.87e-8 0.916 1.15e-8 0.984 8.11e-1 rs8044995 AG 0.173 0.162 16 67709340 68311340 1.081 1.052 1.111 1.51e-8 1.081 3.27e-8 1.090 1.95e-1 rs4523957 TG 0.642 0.627 17 2095899 2220799 1.071 1.049 1.094 2.86e-10 1.071 1.04e-9 1.084 1.05e-1 rs8082590 AG 0.611 0.614 17 17722402 18030202 0.939 0.918 0.960 1.77e-8 0.936 6.84e-9 1.003 9.49e-1 chr18_52749216_D I2D 0.589 0.567 18 52747686 52752696 1.071 1.049 1.093 8.03e-11 1.075 1.75e-11 0.988 8.1e-1 rs78322266 TG 0.0345 0.0292 18 52987176 53172676 1.188 1.120 1.261 1.32e-8 1.194 1.1e-8 1.070 6.53e-1 rs9636107 AG 0.49 0.503 18 53195247 53200117 0.930 0.911 0.949 3.34e-12 0.927 9.09e-13 0.997 9.47e-1 rs72934570 TC 0.0701 0.0797 18 53453389 53585689 0.873 0.839 0.909 1.97e-11 0.865 3.67e-12 1.018 8.37e-1 rs715170 TC 0.261 0.275 18 53769014 53804154 0.935 0.914 0.957 1.27e-8 0.936 3.47e-8 0.926 1.59e-1 rs2905426 TG 0.611 0.628 19 19374022 19658022 0.934 0.914 0.954 3.63e-10 0.937 6.92e-9 0.866 4.23e-3 rs2053079 AG 0.755 0.769 19 30981643 31039023 0.931 0.909 0.954 4.49e-9 0.929 3.79e-9 0.977 6.93e-1 rs56873913 TG 0.775 0.766 19 50067499 50135399 1.071 1.045 1.098 4.69e-8 1.069 2.19e-7 1.108 7.2e-2 rs6065094 AG 0.307 0.322 20 37361494 37485994 0.928 0.908 0.948 1.46e-11 0.928 5.52e-11 0.922 1.15e-1 rs7267348 TC 0.741 0.754 20 48114136 48131649 0.937 0.916 0.959 4.56e-8 0.938 1.18e-7 0.931 1.84e-1 chr22_39987017_D I2D 0.591 0.594 22 39975317 40016817 0.930 0.911 0.951 4.73e-11 0.928 2.2e-11 0.997 9.6e-1 rs9607782 AT 0.25 0.232 22 41408556 41675156 1.087 1.060 1.113 2.07e-11 1.091 6.76e-12 1.005 9.29e-1 rs1023500 TC 0.817 0.81 22 42315744 42361344 1.076 1.048 1.104 3.43e-8 1.076 5.04e-8 1.058 3.73e-1 rs6002655 TC 0.456 0.443 22 42375814 42689414 1.066 1.044 1.088 1.71e-9 1.068 1.48e-9 1.028 5.68e-1 rs12845396 AT 0.739 0.753 X 5916533 6032733 0.947 0.930 0.966 2.21e-8 0.950 3.14e-7 0.890 7.46e-3 rs1378559 TC 0.848 0.831 X 21193266 21570266 1.090 1.064 1.116 1.61e-12 1.088 1.68e-11 1.131 2.88e-2 rs5937157 TG 0.738 0.759 X 68377126 68379036 0.938 0.919 0.956 1.98e-10 0.934 5.74e-11 1.007 8.69e-1