This page contains the material for the course on GWAS given at UH in III period of 2018-2019 as part of Life Science Informatics Msc programme.

Lecture notes and exercises are by Matti Pirinen and distributed under CC-BY-SA license. The slides contain individual figures from literature, as clearly indicated on each slide, and their copyright belongs to the original publisher.

Comments about the content to matti.pirinen'at'helsinki.fi

Notes | Slides | |

1. What is a GWAS? | html pdf Rmd | |

2. P-values in GWAS | html pdf Rmd | |

3. Statistical power | html pdf Rmd | |

4. Bayesian inference | html pdf Rmd | |

5. Relatedness and population structure | html pdf Rmd | |

6. Confounders and covariates | html pdf Rmd | |

7. Linkage disequilibrium (LD) and fine-mapping | html pdf Rmd | |

8. Heritability and mixed models | html pdf Rmd | |

9. Meta-analysis and summary statistics | html pdf Rmd | |

10. Genotype imputation | html pdf Rmd | |

11. Mendelian randomization | html pdf Rmd | |

12. Success and criticism of GWAS |