Publications

2011 -


Brunello CA, Yan X, Huttunen HJ. Internalized Tau sensitizes cells to stress by promoting formation and stability of stress granules. Sci. Rep. 6: 30498, 2016. [abstract] [full text]

Uronen RL, Huttunen HJ. Genetic risk factors of Alzheimer’s disease and cell-to-cell transmission of Tau. J. Neurol. Neuromed. 1(2): 17-22, 2016. [full text] [PDF]

Yan X, Nykänen NP, Brunello CA, Haapasalo A, Hiltunen M, Uronen RL, Huttunen HJ. FRMD4A-cytohesin signaling modulates cellular release of Tau. J. Cell Sci. Apr 4, 2016. [abstract] [full text]

Sakha P, Vesikansa A, Orav E, Heikkinen J, Kukko-Lukjanov TK, Shintyapina A, Franssila S, Jokinen V, Huttunen HJ, Lauri SE. Axonal Kainate Receptors Modulate the Strength of Efferent Connectivity by Regulating Presynaptic Differentiation.
Front. Cell. Neurosci. 10: 3, 2016. [abstract] [full text]

Paatero A, Rosti K, Shkumatov AV, Sele C, Brunello C, Kysenius K, Singha P, Jokinen V, Huttunen H, Kajander T. Crystal Structure of an Engineered LRRTM2 Synaptic Adhesion Molecule and a Model for Neurexin Binding.
Biochemistry 55: 914-26, 2016. [abstract] [full text]

Kysenius K, Huttunen HJ. Stress-induced upregulation of VLDL receptor alters Wnt-signaling in neurons.
Exp. Cell Res. 340: 238-47, 2016. [abstract] [full text]

Savolainen MH*, Yan X*, Myöhänen TT, Huttunen HJ. Prolyl oligopeptidase enhances α-synuclein dimerization via direct protein-protein interaction.
J. Biol. Chem. 290: 5117-26, 2015. [abstract] [full text]

Martiskainen H, Viswanathan J, Nykänen N-P, Kurki M, Helisalmi S, Natunen T, Sarajärvi T, Kurkinen KMA, Pursiheimo J-P, Rauramaa T, Alafuzoff I, Jääskeläinen JE, Leinonen V, Soininen H, Haapasalo A, Huttunen HJ, Hiltunen M. Transcriptomics and mechanistic elucidation of Alzheimer’s disease risk genes in the brain and in vitro models.
Neurobiol. Aging 36: 1221.e15-28, 2015. [abstract] [full text]

Sakha P, Brunello C, Heikkinen J, Jokinen V and Huttunen HJ. "Asymmetric genetic manipulation and patch clamp recording of neurons in a microfluidic chip" Chapter in a book titled “
Microfluidic and Compartmentalized Platforms For Neurobiological Research”. Microfluidic and Compartmentalized Platforms for Neurobiological Research. Neuromethods 103: 59-81, 2015. [full text]

Kysenius K, Brunello CA, Huttunen HJ. Mitochondria and NMDA Receptor-Dependent Toxicity of Berberine Sensitizes Neurons to Glutamate and Rotenone Injury.
PLoS One 9(9): e107129, 2014. [abstract] [full text] [PDF]

Merezhko M, Muggalla P, Nykänen NP, Yan X, Sakha P, Huttunen HJ. Multiplex assay for live-cell monitoring of cellular fates of amyloid-β precursor protein (APP).
PLoS One 9(6): e98619, 2014. [abstract] [full text] [PDF]

Wang W, Mutka A-L, Prosenc Zmrzljak U, Rozman D, Tanila H, Gylling H, Remes AM, Huttunen HJ and Ikonen E. Amyloid precursor protein
α- and β-cleaved ectodomains exert opposing control of cholesterol homeostasis via SREBP2. FASEB J. 28: 849-60, 2014. [abstract]

Antila H, Autio H, Harju K, Tammela P, Wennerberg K, Yli-Kauhaluoma J, Huttunen HJ, Castrén E and Rantamäki T. Utilization of in situ ELISA methodology for examining Trk receptor phosphorylation in cultured cells.
J. Neurosci. Meth. 222: 142-6, 2014. [abstract]

Brunello CA, Jokinen V, Sakha P, Hideyuki T, Nomura F, Kaneko T, Lauri SE, Franssila S, Rivera C, Yasuda K and Huttunen HJ. Microtechnologies to fuel neurobiological research with nanometer precision.
J. Nanobiotechnol. 11: 11, 2013. [abstract]

Jokinen V, Sakha P, Suvanto P, Rivera C, Franssila S, Lauri SE and Huttunen HJ. A microfluidic device for axonal isolation and patch clamp electrophysiological recording.
J. Neurosci. Meth. 212: 276-82, 2013. [abstract]

Kysenius K, Muggalla P, Mätlik K, Arumäe U and Huttunen HJ. Proprotein convertase PCSK9 regulates neuronal apoptosis by adjusting ApoER2 levels and signaling.
Cell. Mol. Life Sci. 69: 1903-1916, 2012. [abstract]

Laakso T, Muggalla P, Kysenius K, Laurén J, Paatero A, Huttunen HJ and Airaksinen MS. LRRTM3 is dispensable for amyloid-β production in mice.
J. Alzheimer's Disease 31: 759-764, 2012. [abstract]

Vesikansa A, Sakha P, Kuja-Panula J, Molchanova S, Rivera C, Huttunen HJ, Rauvala H, Taira T, Lauri SE. Expression of GluK1c underlies the developmental switch in presynaptic kainate receptor function.
Sci. Rep. 2:310, 2012. [abstract] [full text]

Nykänen NP, Kysenius K, Sakha P, Tammela P and Huttunen HJ. γ-aminobutyric acid type A (GABAA) receptor activation modulates Tau phosphorylation.
J. Biol. Chem. 287: 6743-6752, 2012. [abstract]

2001 - 2010

Huttunen HJ, Havas D, Peach C, Barren C, Duller S, Xia W, Frosch MP, Hutter-Paier B, Windisch M and Kovacs DM. The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice. J. Neuropathol. Exp. Neurol. 69: 777-788, 2010. [abstract]

Tsoporis JN, Izhar S, Leong-Poi H, Desjardins JF, Huttunen HJ and Parker TG. S100B interaction with the receptor for advanced glycation end products (RAGE): A novel receptor-mediated mechanism for myocyte apoptosis postinfarction.
Circ. Res. 106: 93-101, 2010. [abstract]

Huttunen HJ, Peach C, Bhattacharyya R, Barren C, Pettingell W, Hutter-Paier B, Windisch M, Berezovska O and Kovacs DM. Inhibition of Acylcoenzyme A: Cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway.
FASEB J. 23: 3819-28, 2009. [abstract]

Shulga A, Blaesse A, Kysenius K, Huttunen HJ, Tanhuanpää K, Saarma M and Rivera C. Thyroxin regulates BDNF expression to promote survival of injured neurons.
Mol. Cell. Neurosci. 42: 408-418, 2009. [abstract]

Huttunen HJ, Puglielli L, Ellis BC, MacKenzie Ingano LA, Kovacs DM. Novel N-terminal cleavage of APP precludes Abeta generation in ACAT-defective AC29 cells.
J. Mol. Neurosci. 37: 6-15, 2009. [abstract]

Huttunen HJ, Kovacs DM. ACAT as a drug target for Alzheimer's disease.
Neurodegener. Dis. 5: 212-214, 2008. [abstract]

Huttunen HJ, Guenette SY, Peach C, Greco C, Xia WM, Kim DY, Barren C, Tanzi RE and Kovacs DM. HtrA2 regulates APP metabolism through ER-associated degradation.
J. Biol. Chem. 282: 28285-95, 2007. [abstract]

Huttunen HJ, Greco C, Kovacs DM. Knockdown of ACAT-1 reduces amyloidogenic processing of APP.
FEBS Lett. 581: 1688-1692, 2007. [abstract]

Hutter-Paier B, Huttunen HJ, Puglielli L, Eckman CB, Kim DY, Hofmeister A, Moir RD, Domnitz SB, Frosch MP, Windisch M and Kovacs DM. The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer’s disease.
Neuron 44: 227-238, 2004. [abstract]

Huttunen HJ, Rauvala H. Amphoterin as an extracellular regulator of cell motility: from discovery to disease.
J. Intern. Med. 255: 351-366, 2004. [abstract]

Münch G, Gasic-Milenkovic J, Dukic-Stefanovic S, Kuhla B, Heinrich K, Riederer P, Huttunen HJ, Founds H, Sajithlal G. Microglial activation induces cell death, inhibits neurite outgrowth and causes neurite retraction of differentiated neuroblastoma cells.
Exp. Brain Res. 150: 1-8, 2003. [abstract]

Huttunen HJ, Fages C, Kuja-Panula J, Ridley AJ, Rauvala H. Receptor for advanced glycation end products-binding COOH-terminal motif of amphoterin inhibits invasive migration and metastasis.
Cancer Res. 62: 4805-4811, 2002. [abstract]

Huttunen HJ, Kuja-Panula J, Rauvala H. Receptor for advanced glycation end products (RAGE) signaling induces CREB-dependent chromogranin expression during neuronal differentiation.
J. Biol. Chem. 277: 38635-38646, 2002. [abstract]

Srikrishna G, Huttunen HJ, Johansson L, Weigle B, Yamaguchi Y, Rauvala H, Freeze HH. N-Glycans on the receptor for advanced glycation end products influence amphoterin binding and neurite outgrowth.
J. Neurochem. 80: 998-1008, 2002. [abstract]

- 2000

Huttunen HJ, Kuja-Panula J, Sorci G, Agneletti AL, Donato R, Rauvala H. Coregulation of neurite outgrowth and cell survival by amphoterin and S100 proteins through receptor for advanced glycation end products (RAGE) activation. J. Biol. Chem. 275: 40096-40105, 2000. [abstract] [PDF]

Rauvala H, Huttunen HJ, Fages C, Kaksonen M, Kinnunen T, Imai S, Raulo E, Kilpeläinen I. Heparin-binding proteins HB-GAM (pleiotrophin) and amphoterin in the regulation of cell motility.
Matrix Biol. 19: 377-387, 2000. [abstract]

Fages C, Nolo R, Huttunen HJ, Eskelinen E, Rauvala H. Regulation of cell migration by amphoterin.
J. Cell Sci. 113: 611-620, 2000. [abstract] [PDF]

Huttunen HJ, Fages C, Rauvala H. Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-kappaB require the cytoplasmic domain of the receptor but different downstream signaling pathways.
J. Biol. Chem. 274: 19919-19924, 1999. [abstract] [PDF]


Ph.D. theses

Xu Yan. New insight into mechanisms of transcellular propagation of tau and α-synuclein in neurodegenerative diseases. University of Helsinki. Febraury, 2017. [Link]

Prasanna Sakha. Development of microfluidic applications to study the role of kainate receptors in synaptogenesis. University of Helsinki. April, 2016 (co-supervised by Dr. Sari Lauri). [Link]

Niko-Petteri Nykänen. Cellular physiology and cell-to-cell propagation of Tau in neurodegeneration: The impact of late-onset Alzheimer's disease susceptibility genes. University of Helsinki. January, 2016. [Link]


Kai Kysenius. PCSK9 and berberine as modulators of lipoprotein receptors and neuronal cell death. University of Helsinki. May, 2015. [Link]


Patent applications

Puglielli L, Huttunen HJ, Guenette SY, Tanzi RE, Kovacs DM. Methods and compositions relating to modulating amyloid precursor protein cleavage. US patent application 2005/0170,437. Link