β-Carotene and vitamin D -papers

by Harri Hemilä


Department of Public Health
University of Helsinki, Finland
Harri.hemila@helsinki.fi
http://www.mv.helsinki.fi/home/hemila
Aug 6, 2020
β-Carotene

Vitamin D




β-Carotene


Original articles


β-Carotene effect on mortality depeds on smoking and on vitamins C and E
Hemilä H
The effect of β-carotene on the mortality of male smokers is modified by smoking and by vitamins C and E: evidence against a uniform effect of nutrient
J Nutr Sci 2020
https://doi.org/10.1017/jns.2020.3
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7082716

β-Carotene increases the risk of pneumonia, depending on smoking

Hemilä H
Effect of β-Carotene Supplementation on the Risk of Pneumonia Is Heterogeneous in Males: Effect Modification by Cigarette Smoking
J Nutr Sci Vitaminol (Tokyo) 2018
https://doi.org/10.3177/jnsv.64.374


The effect of β-carotene on common cold incidence is heteroteneous depending on age and smoking
No good evidence of preventive effects in any group, but evidence of harm in some groups
Hemilä H
The effect of β-carotene on common cold incidence is modified by age and smoking: evidence against a uniform effect in a nutrient-disease relationship.
Nutrition and Dietary Supplements 2010
http://dx.doi.org/10.2147/NDS.S13299
http://www.dovepress.com/article_5490.t2368605

β-Carotene supplementation does not prevent TB
Hemilä H, Kaprio J
Vitamin E supplementation may transiently increase tuberculosis risk in males who smoke heavily and have high dietary vitamin C intake. [Discussion: 2009;101:145-147]
Br J Nutr 2008
http://dx.doi.org/10.1017/S0007114508923709
http://www.ncbi.nlm.nih.gov/pubmed/18279551
(Discussion: http://dx.doi.org/10.1017/S0007114508994423   http://dx.doi.org/10.1017/S0007114508994411 )

β-Carotene supplementation does not prevent pneumonia in participants who exercise or carry out heavy work
Hemilä H, Kaprio J, Albanes D, Virtamo J
Physical activity and pneumonia in male smokers administered vitamin E and β-carotene.
Int J Sports Med 2006
http://hdl.handle.net/10138/18749   
http://dx.doi.org/10.1055/s-2005-865670
http://www.ncbi.nlm.nih.gov/pubmed/16572378
http://www.mv.helsinki.fi/home/hemila/H/2006_IJSM.pdf 

Hemilä H, Virtamo J, Albanes D, Kaprio J
Vitamin E and beta-carotene supplementation and hospital-treated pneumonia incidence in male smokers.
Chest 2004
http://dx.doi.org/10.1378/chest.125.2.557
http://www.ncbi.nlm.nih.gov/pubmed/14769738
http://www.mv.helsinki.fi/home/hemila/H/2004_Chest.pdf

Hemilä H, Virtamo J, Albanes D, Kaprio J
Physical activity and the common cold in men administered vitamin E and β-carotene.
MSSE 2003
http://hdl.handle.net/10138/18380  
http://dx.doi.org/10.1249/01.MSS.0000093616.60899.92
http://www.mv.helsinki.fi/home/hemila/H/2003_MSSE.pdf
http://www.ncbi.nlm.nih.gov/pubmed/14600543

Hemilä H, Kaprio J, Albanes D, Heinonen OP, Virtamo J
Vitamin C, vitamin E and beta-carotene in relation to common cold incidence in male smokers.
Epidemiology 2002
http://hdl.handle.net/10138/18059 
http://dx.doi.org/10.1097/00001648-200201000-00006
http://www.jstor.org/pss/3703244
http://www.mv.helsinki.fi/home/hemila/H/2002_Epidemiology.pdf
http://www.ncbi.nlm.nih.gov/pubmed/11805583


The harms of β-carotene supplementation may be caused by carotene cleavage products including vitamin A derivatives
Hemilä H, Wikström M.
Retinoids activate superoxide production by polymorphonuclear leucocytes.
Scand J Immunol. 1985
https://www.ncbi.nlm.nih.gov/pubmed/2986277



Letters and commentaries in English

Hemilä H
Antioxidants are not identical and their effects are not uniform over the population [Feedback].
[Comments on the Cochrane review “Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases” by Bjelakovic G et al.]
https://helda.helsinki.fi/handle/10138/136201



Vitamin D


Problems in a meta-analysis in BMJ on vitamin D and the common cold
Hemilä H
Statistical problems in the vitamin D and respiratory infection meta-analysis
BMJ eLetter 2017
http://www.bmj.com/content/356/bmj.i6583/rr-3

The author's responses were not valid
Hemilä H
Hemilä’s response to professor Martineau
BMJ eLetter 2017
http://www.bmj.com/content/356/bmj.i6583/rr-8


Dubnov-Raz G, Rinat B, Hemilä H, Choleva L, Cohen AH, Constantini NW.
Vitamin D supplementation and upper respiratory tract infections in adolescent swimmers: a randomized controlled trial.
Pediatr Exerc Sci. 2015;27(1):113-9
https://www.ncbi.nlm.nih.gov/pubmed/25050610

Hemilä H.
Vitamin D level, respiratory tract infections, and controlled trials.
Arch Intern Med. 2009;169(15):1443
https://www.ncbi.nlm.nih.gov/pubmed/19667312