Vitamin E for mortality and acute kidney injury

by Harri Hemilä


Department of Public Health
University of Helsinki, Finland
harri.hemila@helsinki.fi
http://www.mv.helsinki.fi/home/hemila
Aug 6, 2020

  1. Original articles and systematic reviews

  2. Letters and commentaries

 

Original articles and systematic reviews

Further evidence of heterogeneity in the effects of vitamin E on mortality
Hemilä H.
Vitamin E and Mortality in Male Smokers of the ATBC Study: Implications for Nutritional Recommendations.
Frontiers in Nutrition 2020
https://doi.org/10.3389/fnut.2020.00036
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7136753

In three RCTs vitamin E decreased the rate of acute kidney injury in participants going to angiography
Rezaei Y, Hemilä H
Vitamins E and C May Differ in Their Effect on Contrast-Induced Acute Kidney Injury
American Journal of Kidney Diseases 2017
https://doi.org/10.1053/j.ajkd.2016.12.022
http://www.mv.helsinki.fi/home/hemila/H/2017_L_AJKD.pdf

In Finnish male smokers, vitamin E extended life span by half a year
Hemilä H, Kaprio J.
Vitamin E may affect the life expectancy of men, depending on dietary vitamin C intake and smoking.
Age Ageing 2011;40:215-220
http://dx.doi.org/10.1093/ageing/afq178
http://www.ncbi.nlm.nih.gov/pubmed/21242192
Prepublication history:
http://www.mv.helsinki.fi/home/hemila/PPH/AA/AA.html

Very strong evidence that vitamin E effect on mortality is modified by age and dietary vitamin C intake (P = 0.0005)
Hemilä H, Kaprio J.
Modification of the effect of vitamin E supplementation on the mortality of male smokers by age and dietary vitamin C.
Am J Epidemiol 2009;169:946-953
http://dx.doi.org/10.1093/aje/kwn413
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661323
http://www.ncbi.nlm.nih.gov/pubmed/19218294

Letters and commentaries

Hemilä H
Comparison of different vitamin E forms is confounded by heterogeneity in vitamin E effects.
Nutrition Reviews 2018
https://doi.org/10.1093/nutrit/nuy038

Hemilä H, Rezaei Y
Vitamin E May Protect Against Contrast-Induced Acute Kidney Injury
Journal of the American College of Cardiology 2017
https://doi.org/10.1016/j.jacc.2016.11.091  
http://www.mv.helsinki.fi/home/hemila/H/2017_L_JACC.pdf

Hemilä H.
Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer.
Ann Intern Med 2014;160:655.
http://dx.doi.org/10.7326/L14-5009-3 
http://www.mv.helsinki.fi/home/hemila/H/2014_L_AIMed.pdf

Hemilä H.
Vitamin E may significantly increase and decrease mortality in some population groups.
PLoS ONE [Comment 27 Oct 2013]
http://www.plosone.org/annotation/listThread.action?root=73909

Hemilä H.
Vitamin supplements and mortality in older people.
AJCN 2013;98:502
http://dx.doi.org/10.3945/ajcn.113.064204
http://www.mv.helsinki.fi/home/hemila/H/2013_L_AJCN.pdf

Hemilä H.
Vitamin E may extend life span of older males irrespective of the meta-analysis by Myung et al.
BMJ [Rapid Response 5 Feb 2013]
http://www.bmj.com/content/346/bmj.f10/rr/629228

Hemilä H.
Antioxidants are not identical and their effects are not uniform over the population.
[Feedback on the Cochrane review “Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases” by Bjelakovic G et al.]
Cochrane Database of Systematic Reviews CD007176 [Feedback 24 August 2009]
http://hdl.handle.net/10138/136201
http://dx.doi.org/10.13140/2.1.4426.0641


Hemilä H.
Vitamin E is likely to affect mortality even at low doses.
Clinical Trials 2009;6:392-393
http://dx.doi.org/10.1177/1740774509340211
https://helda.helsinki.fi/handle/10138/16982
http://www.mv.helsinki.fi/home/hemila/H/2009_L_ClinTrials_2p.pdf

Hemilä H.
Spectacular reduction in the mortality of acutely injured patients by the administration of vitamins C and E and selenium.
JPEN 2009;33:447-448
http://dx.doi.org/10.1177/0148607108328520
http://www.mv.helsinki.fi/home/hemila/H/2009_L_JPEN.pdf
http://hdl.handle.net/10138/16985

Hemilä H.
Antioxidant supplements and mortality.
JAMA 2007;298:401
http://dx.doi.org/10.1001/jama.298.4.401-a
http://www.mv.helsinki.fi/home/hemila/H/2007_L_JAMA.pdf

Hemilä H, Miller ER.
Evidence-based medicine and vitamin E supplementation.
AJCN 2007;86:261-262
http://www.ajcn.org/cgi/content/full/86/1/261
http://www.mv.helsinki.fi/home/hemila/H/2007_L_AJCN.pdf

Hemilä H.
High-dosage vitamin E supplementation and all-cause mortality.
Ann Intern Med 2005;143:156-157
http://dx.10.7326/0003-4819-143-2-200507190-00020 
http://www.mv.helsinki.fi/home/hemila/H/2005_L_AIMed.pdf