Vitamin E for mortality and acute kidney injury

by Harri Hemilä

Department of Public Health
University of Helsinki, Finland
Oct 14, 2022

  1. Original articles and systematic reviews

  2. Letters and commentaries


Original articles and systematic reviews

Further evidence of heterogeneity in the effects of vitamin E on mortality
Hemilä H.
Vitamin E and Mortality in Male Smokers of the ATBC Study: Implications for Nutritional Recommendations.
Frontiers in Nutrition 2020

In three RCTs vitamin E decreased the rate of acute kidney injury in participants going to angiography
Rezaei Y, Hemilä H
Vitamins E and C May Differ in Their Effect on Contrast-Induced Acute Kidney Injury
American Journal of Kidney Diseases 2017

In Finnish male smokers, vitamin E extended life span by half a year
Hemilä H, Kaprio J.
Vitamin E may affect the life expectancy of men, depending on dietary vitamin C intake and smoking.
Age Ageing 2011;40:215-220

Very strong evidence that vitamin E effect on mortality is modified by age and dietary vitamin C intake (P = 0.0005)
Hemilä H, Kaprio J.
Modification of the effect of vitamin E supplementation on the mortality of male smokers by age and dietary vitamin C.
Am J Epidemiol 2009;169:946-953

Letters and commentaries

Hemilä H
Comparison of different vitamin E forms is confounded by heterogeneity in vitamin E effects.
Nutrition Reviews 2018

Hemilä H, Rezaei Y
Vitamin E May Protect Against Contrast-Induced Acute Kidney Injury
Journal of the American College of Cardiology 2017

Hemilä H.
Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer.
Ann Intern Med 2014;160:655.

Hemilä H.
Vitamin E may significantly increase and decrease mortality in some population groups.
PLoS ONE [Comment 27 Oct 2013]

Hemilä H.
Vitamin supplements and mortality in older people.
AJCN 2013;98:502

Hemilä H.
Vitamin E may extend life span of older males irrespective of the meta-analysis by Myung et al.
BMJ [Rapid Response 5 Feb 2013]

Hemilä H.
Antioxidants are not identical and their effects are not uniform over the population.
[Feedback on the Cochrane review “Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases” by Bjelakovic G et al.]
Cochrane Database of Systematic Reviews CD007176 [Feedback 24 August 2009]

Hemilä H.
Vitamin E is likely to affect mortality even at low doses.
Clinical Trials 2009;6:392-393

Hemilä H.
Spectacular reduction in the mortality of acutely injured patients by the administration of vitamins C and E and selenium.
JPEN 2009;33:447-448

Hemilä H.
Antioxidant supplements and mortality.
JAMA 2007;298:401

Hemilä H, Miller ER.
Evidence-based medicine and vitamin E supplementation.
AJCN 2007;86:261-262

Hemilä H.
High-dosage vitamin E supplementation and all-cause mortality.
Ann Intern Med 2005;143:156-157