Department
of Public Health
University of Helsinki,
Finland
harri.hemila@helsinki.fi
https://www.mv.helsinki.fi/home/hemila
Oct 14, 2022
In
3 RCTs vitamin C halved the FEV1 decline caused by exercise:
Hemila
H.
The
effect of vitamin C on bronchoconstriction and respiratory symptoms
caused by exercise: a review and statistical analysis.
Allergy,
Asthma and Clinical Immunology
2014;10:58
https://doi.org/10.1186/1710-1492-10-58
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363347
Hemila
H
Vitamin
C may alleviate exercise-induced bronchoconstriction: a
meta-analysis
BMJ
Open 2013;3:e002416
https://doi.org/10.1136/bmjopen-2012-002416
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686214
Heavy
short-term physical stress subgroup in this analysis:
Hemila
H, Chalker EB
Vitamin
C for preventing and treating the common cold.
Cochrane
Database of Systematic Reviews 2013; CD000980
https://doi.org/10.1002/14651858.CD000980.pub4
https://helda.helsinki.fi/handle/10138/225864
https://www.mv.helsinki.fi/home/hemila/CC/CC.htm
References to the
review:
https://www.mv.helsinki.fi/home/hemila/CC
Vitamin
C halved the duration of colds in male adolescent swimmers but not in
female adolescent swimmers:
Constantini
NW, Dubnov-Raz G, Eyal BB, Berry EM, Cohen AH, Hemila H
The
effect of vitamin C on upper respiratory infections in adolescent
swimmers: a randomized trial
European
Journal of Pediatrics
2011;170:59-63
https://doi.org/10.1007/s00431-010-1270-z
https://helda.helsinki.fi/handle/10138/228085
https://www.mv.helsinki.fi/home/hemila/H/HH_2011_EurJPediatr.pdf
Effects
of vitamin C on military personnel may be explained by heavy physical
stress or/and crowding of people:
Hemila
H
Vitamin
C supplementation and respiratory infections: a systematic review.
Military
Medicine 2004;169:920-925
https://doi.org/10.7205/MILMED.169.11.920
https://www.mv.helsinki.fi/home/hemila/H/HH_2004.pdf
The
first meta-analysis on the effect of vitamin C on people under heavy
short-term physical stress which was based on 3 RCTs
Hemila
H
Vitamin
C and common cold incidence: a review of studies with subjects under
heavy physical stress.
International
Journal of Sports Medicine 1996;17:379-383
https://doi.org/10.1055/s-2007-972864
https://helda.helsinki.fi/handle/10138/225881
https://www.mv.helsinki.fi/home/hemila/H/HH_1996_IJSM.pdf
Hemila
H
Vitamin
C should be tested against exercise-induced
bronchoconstriction
American
Journal of Respiratory and Critical Care Medicine 2013;188(11):1370.
https://doi.org/10.1164/rccm.201307-1205LE
Meta-analysis
of 3 exercise-induced asthma trials and pointing out errors in the
Cochrane review
This was expanded to the BMJ Open paper in 2013,
see above
The
Cochrane review on vitamin C and asthma misled readers for a decade
from 2001 to 2013
Hemila
H.
Feedback
[Comments on
the Cochrane review “vitamin C supplementation for asthma” by
Kaur B, Rowe BH, Stovold E]
Cochrane Database of Systematic
Reviews, Feedback 24 March
2009
https://helda.helsinki.fi/handle/10138/225865
https://helda.helsinki.fi/handle/10138/38500
https://doi.org/10.1002/14651858.CD000993.pub3
The
above comment was submitted in 2009, but the authors replied no
earlier than in 2012.
Furthermore, the reply
was full of errors:
Hemila H
Vitamin
C and exercise-induced bronchoconstriction:
further problems in the Cochrane review "vitamin C for asthma"
(2013).
Unpublished commentary
https://hdl.handle.net/10138/40816
Hemila
H
Vitamin
C and exercise-induced bronchoconstriction in athletes
Journal
of Allergy and Clinical Immunology
2009:123:274-275
https://doi.org/10.1016/j.jaci.2008.10.004
https://www.mv.helsinki.fi/home/hemila/H/2009_L_JACI_1.pdf
Comments
on vitamin C and exercise studies:
Hemila
H
Evidence-based
medicine and the role of antioxidants in physically-stressed
people
Nutrition
Reviews
2009;67:61-63
https://doi.org/10.1111/j.1753-4887.2008.00134.x
https://helda.helsinki.fi/handle/10138/228068
https://www.mv.helsinki.fi/home/hemila/H/2009_L_NutRev.pdf
Hemila
H
Vitamin
C and exercise-induced immunodepression
European
Journal of Clinical Nutrition
2007;61:1241-1242
https://doi.org/10.1038/sj.ejcn.1602751
https://helda.helsinki.fi/handle/10250/135144
https://www.mv.helsinki.fi/home/hemila/H/2007_L_EJCN.pdf
Hemila
H
The
effect of nutrition on exercise-induced immunodepression
Nutrition
Reviews
2006;64:476-477
https://doi.org/10.1111/j.1753-4887.2006.tb00179.x
https://www.mv.helsinki.fi/home/hemila/H/2006_L_NutRev.pdf
Effect
of vitamin E on pneumonia is modified by exercise:
Hemila
H, Kaprio J.
Subgroup
analysis of large trials can guide further research: a case study of
vitamin E and pneumonia.
Clinical
Epidemiology
2011;3:51-59
https://doi.org/10.2147/CLEP.S16114
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046185
Effect
of vitamin E on pneumonia is modified by exercise:
Hemila
H, Kaprio J, Albanes D, Virtamo J.
Physical
activity and pneumonia in male smokers administered vitamin E and
β-carotene.
International
Journal of Sports Medicine 2006;27:336-341
https://doi.org/10.1055/s-2005-865670
https://helda.helsinki.fi/handle/10138/18749
Vitamin
E does not influence colds in middle-aged men doing exercises:
Hemila
H, Virtamo J, Albanes D, Kaprio J.
Physical
activity and the common cold in men administered vitamin E and
β-carotene.
Medicine
and Science in Sports and Exercise 2003;35:1815-1820
https://doi.org/10.1249/01.MSS.0000093616.60899.92
https://hdl.handle.net/10138/18380
Comments
on vitamin E and exercise studies:
Hemila
H
Evidence-based
medicine and the role of antioxidants in physically-stressed
people
Nutrition
Reviews
2009;67:61-63
https://doi.org/10.1111/j.1753-4887.2008.00134.x
https://helda.helsinki.fi/handle/10138/228068
https://www.mv.helsinki.fi/home/hemila/H/2009_L_NutRev.pdf
Hemila H
The
effect of nutrition on exercise-induced immunodepression
Nutrition
Reviews
2006;64:476-477
https://doi.org/10.1111/j.1753-4887.2006.tb00179.x
https://www.mv.helsinki.fi/home/hemila/H/2006_L_NutRev.pdf