Vitamin C for preventing and treating pneumonia

Cochrane review  doi:10.1002/14651858.CD005532.pub3 

by Harri Hemilš and Pekka Louhiala

        Summary of the findings and a discussion of implications:
        J R Soc Med 2007  JRSM 2007 in PMC 



The 2013 version is available here:
http://www.mv.helsinki.fi/home/hemila/CP/CochranePneumonia_2013.pdf

In 2016 we updated the review, and the review is available here:
http://www.mv.helsinki.fi/home/hemila/CP/CochranePneumonia_2016.pdf



Cochrane Collaboration rejected the above 2016 update for reasons that are not related to the scientific validity of the review.
In June 2016 we responded to reviewer comments:
http://www.mv.helsinki.fi/home/hemila/CP/ARI_June2016_pneu_responses.pdf

Our responses to the comments of
Mark Jones from the Cochrane Acute Respiratory Infections (ARI) group,
are available here:
http://www.mv.helsinki.fi/home/hemila/CP/MarkJones_pneu_responses.pdf

None of the Mark Jones' comments pointed out any genuine scientific problems in our 2016 update.
Many of his comments reveal that he did not read our 2016 update carefully, see youself.

The rejection decision in February 2017 by Chris Del Mar did not point out any specific scientific reasons for the rejection:
http://www.mv.helsinki.fi/home/hemila/CP/ChrisDelMar_2017_pneu_comments.pdf

None of the above comments pointed out any genuine scientific problems in our 2016 update, read the comments and responses yourself.


References available via internet:

Contents

  1. Included trials 
  2. Excluded trials  
  3. Other references
Harri Hemilš
Department of Public Health,
 University of Helsinki,  Helsinki, Finland
harri.hemila@helsinki.fi
Home:  http://www.mv.helsinki.fi/home/hemila

This file:  http://www.mv.helsinki.fi/home/hemila/CP
Papers on pneumonia and other serious infections:
http://www.mv.helsinki.fi/home/hemila/vitc_pneumonia.htm
 Feb 18, 2020


Included trials 

Glazebrook 1942_PMC    Glazebrook 1942 ch    Glazebrook 1942 tables
     Comment in BMJ 1942 June by the authors
     Comment in BMJ 1942 commentary
     Comment in BMJ 1942 Nov by the authors
     Comment in BMJ 1944 Nov by the authors  
     Description of the study backgound via an earlier paper in J Hyg (1941)

       Pauling's analysis
http://scarc.library.oregonstate.edu/coll/pauling/rnb/31/31-103.html
http://scarc.library.oregonstate.edu/coll/pauling/rnb/33/33-034.html
http://scarc.library.oregonstate.edu/coll/pauling/rnb/33/33-035.html

Hunt 1994 ch   Hunt 1994 bm   Hunt 1994 PubMed

Kimbarowski 1967 translation   Kimbarowski 1967 PubMed
    Kimbarowski 1967 German ch     Kimbarowski 1967 German bm

Mochalkin 1970 translation         Mochalkin 1970 PubMed
       Mochalkin 1970 Russian ch   Mochalkin 1970 Russian bm

       Mochalkin 1974 translation (same data as in 1970)
       Mochalkin 1974 (OCR characters in Russian)        Mochalkin 1974 bm       Mochalkin 1974 PubMed

       Mochalkin 1975 translation (republication of 1970 with 2 vitC groups combined)  
       Mochalkin 1975 (OCR characters in Russian)
       Mochalkin 1975 (OCR characters in Russian)          Mochalkin 1975 bm       Mochalkin 1975 PubMed

Pitt 1979 doi     Pitt 1979 PubMed    Pitt 1979 ch     Pitt 1979 bm

Tanaka 2000 Doi   Tanaka 2000 PubMed



Excluded trials  


Cook 2007 doi   Cook 2007 PMC   Cook 2007 PubMed

Dahlberg 1944 doi    Dahlberg 1944 ch   Dahlberg 1944 bm 

Hunt 1984 ch       Hunt 1984 bm    Hunt 1984 PubMed

Kahn 2011 doi    Kahn 2011 PubMed

Mahalanabis 2006a doi 

Mahalanabis 2006b bm 

Nathens 2002 PMC    Nathens 2002 PubMed    Nathens 2002 doi

Pico Sirvent 2013      Pico Sirvent 2013 Poster.pdf

Scheunert 1949 ch   Scheunert 1949 bm

Sesso 2008 doi    Sesso 2008 PMC    Sesso 2008 PubMed
  
Sirvent 2013 Poster    Sirvent 2013 Poster.pdf

Wahed 2008 bm

    Ongoing studies

Lafargue 2015 ClinicalTrials.gov



Other references
Reviews on pneumonia available via the net:

Consensus Guidelines on the Management of Community‐Acquired Pneumonia in Adults

wiki Pneumonia
wiki Viral_pneumonia
nytimes pneumonia
MEDLINEPLUS
brighamandwomens


******
Other references cited in the Cochrane Review

Akaike 2001 PubMed
Albaum 1996 doi     Albaum 1996 PubMed 
Anderson 1973 PMC   Anderson 1972 PMC    Anderson 1972 and 1973 ch
Ashor 2014 doi
Ashton 1999 PubMed

Baik 2000 doi
Bakaev 2004 PubMed     Bakaev 2004 fulltext
Beisel 1982  AJCN
Bhoite 2011
Bissell 1980 PubMed
Bjordahl 2012 PubMed
Bloomfield 1999 doi
Bohnholzer 1937 translation    Bohnholzer 1937 ch    Bohnholzer 1937 bm
    see also:      Gunzel 1937 ch    Gunzel 1937 bm
Briggs 1984 Ref List
Bruno 2006 PubMed
Buffinton 1992 PubMed     Buffinton 1992 doi

Carpenter 1986 Cambridge      Carpenter 1986 Amazon   Carpenter 1986 BookReview   Carpenter 1986 BookReview
Cathcart 1981 doi   Cathcart 1981 PubMed  paper available via links 
Cemek 2006 PubMed
Chakrabarti 1955 ch    Chakrabarti 1955 bm   Chakrabarti 1955 PubMed
Dalton 1962 ch    Dalton 1962    Dalton 1962 bm   Dalton 1962 PubMed    
Dehghani 2014 PubMed
Dirlewanger 2002 PubMed    Dirlewanger 2002 doi
Doherty 1991 doi

Elwood 1976 doi    Elwood 1976 PMC  Elwood 1976 JECH    Elwood 1976 ch (54 KB)  
Gaffey 1996 Doi    Galley 1996 PubMed    
Gander 1936 translation   Gander 1936 ch     Gander 1936 bm
Goetzl 1974 PubMed
Goodwin 1998 doi       Goodwin 1998 PubMed
Hathcock 2005 AJCN 

Hemilš 1984 doi
Hemilš 1992 doi        Hemilš 1992     Hemilš 1992 Manu with links to Refs           Hemilš 1992 PubMed
Hemilš 1996 doi        Hemilš 1996     Hemilš 1996 Manu with links to Refs           Hemilš 1996 PubMed
Hemilš 1996a doi      Hemilš 1996a      Hemilš 1996a Manu with links to Refs     Hemilš 1996a PubMed
   Discussion:  Chalmers 1996     Hemilš 1996 Manu with links to Refs                   Hemilš 1996    Hemilš 1996 
Hemilš 1996b doi     Hemila 1996b    Hemilš 1996b Manu with links to Refs       Hemilš 1996b PubMed
Hemilš 1997 doi        Hemilš 1997 manu with links to Refs   Hemilš 1997
Hemilš 1997a pt I     Hemilš 1997a pt II  
Hemilš 1997b doi     Hemilš 1997b         Hemilš 1997b PubMed    Discussion   Discussion
Hemilš 1999 doi        Hemilš 1999 hdl links to refs    Hemilš 1999 PubMed

Hemilš 2004a doi
Hemilš 2004b doi
Hemilš 2006                  Hemilš 2006       Hemilš 2006    
Hemilš 2007a doi        Hemilš 2007a PMC
Hemilš 2009a doi        Hemilš 2009a PMC
Hemilš 2011a doi        Hemilš 2011a PMC
Hemilš 2013a doi        Hemilš 2013a
http://www.mv.helsinki.fi/home/hemila/CC/CochraneColds_2013.pdf
        References to the Cochrane review vitamin C and the common cold
Hemilš 2013b doi      
Hemilš 2013c doi      Hemilš 2013c PMC
Hemilš 2014 doi        Hemilš 2014 PMC

Hess 1920 (search book author = Hess)   Hess 1920 pages 88 and 99
Hess 1932 NEJM doi  Hess 1932 ch   Hess 1932 bm
     also: Hess 1932 JAMA doi 
Higgins 2003 doi     Higgins 2003 
Higgins 2011  
Hochwald 1937 translation    Hochwald 1937 ch   Hochwald 1937 bm
Holley 2011 PubMed
Hopstaken 2004 doi  Hopstaken 2004 PubMed   
Hrobjartsson 2010 doi
Hughes 1988 ch   Hughes 1988 bm

Ioannidis 2007 doi   Ioannidis 2007 PubMed
IOM 2000   IOM 2000 p. 95 
Jones 1982 ch     Jones 1982 bm
Juraschek 2012 doi      Juraschek 2012 PubMed

Karlowski 1975 doi   Karlowski 1975 PubMed
Kiekara 1996 doi       Kiekara 1996 PubMed  
Kinsman 1971 AJCN
Klenner 1948 ch       Klenner 1948   Klenner 1948 bm   paper available via links
Klenner 1951 ch       Klenner 1951   Klenner 1951 bm    paper available via links

Lau 2006 doi               Lau 2006 PubMed
Levine 1999 doi         Levine 1999 PubMed
Li 2006 J Nutr             Li 2006 PubMed
Louhiala 2014 doi      Louhiala 2014 hdl
Luberoff 1978 ch       Luberoff 1978 bm
Lydersen 2009 doi     Lydersen 2009 PubMed

Mandal 2011 doi                      Mandal 2011 PubMed
Manning 2013 doi                   Manning 2013 PMC         Manning 2013 PubMed
Manzella 1979  J Immunol    Manzella 1979 PubMed 
May 2013 doi                            May 2013 PMC                 May 2013 PubMed
Melbye 1992 doi                      Melbye 1992 PubMed         
Merchant 2004 J Nutr
Mizgerd 2006 doi
Mosdol 2008 doi                      Mosdol 2008 PubMed
Musher 2007 doi                     Musher 2007 PubMed
Musher 2014 doi
Nualart 2003 doi                    Nualart 2003 PubMed

Packer 1979 doi
Padayatty 2004 doi
Padayatty 2010 doi        Padayatty 2010 PubMed
Papoulidis 2011 PubMed
Paynter 2010 doi            Paynter 2010 PubMed
Pazzaglia 1983 ch          Pazzaglia 1983 bm
Pio 2003 Bull WHO
Powers 2008 doi            Powers 2008 PubMed
Prina 2015 doi

R-project
Rayment 2003 doi     Rayment 2003 PubMed
Raynaud-Simon 2010 doi     Raynaud-Simon 2010 PubMed
Rice 2000 doi    Rice 2000 PubMed
Rivers 1987 doi     Rivers 1987 PubMed  
Robertsson 1934 doi    Robertsson 1934 ch    Robertsson 1934 bm
      Other old reviews on vitamin C and infections:
      Perla 1937 pt I     Perla 1937 pt II
      Clausen 1934
Ruuskanen 2011 doi     Ruuskanen 2011 PubMed   

Sabin 1939 doi     Sabin 1939 PMC
Sadeghpour 2015 PubMed     Sadeghpour 2015 PMC
Sarzaeem 2014 Translation
Schleicher 2009 doi      Schleicher 2009 PubMed
Self_2015
Siegel 1975 doi
Slotkin 1944      Slotkin 1944     Slotkin 1944     Slotkin 1944
Sterne 2011 doi    Sterne 2011 PubMed
Swingler 1998 doi
Syrjšlš 1998 doi
Terrin 2005 doi
Thomas 1978 PMC  

Walker 2013 doi     Walker 2013 PubMed
Wang 1997 doi     Wang 1997 PubMed  
Wang 2012 PubMed
Wang 2013 doi  Wang 2013 PubMed
Webb 2007 doi  
WHO 1999a    WHO 1999a   WHO 1999a
    see also: CDC_Somalia    Desenclos (Bull WHO 1989) PMC   Desenclos 1989
WHO 1999b doi     WHO 1999b fulltext
Young 1994 doi   Young 1994 PubMed    
Zhang 2011 doi   Zhang_2011 PubMed


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