Department of Public Health
University of
Helsinki,
Finland
harri.hemila@helsinki.fi
https://www.mv.helsinki.fi/home/hemila
Oct 14, 2022
Further evidence
of heterogeneity in the effects of vitamin E on mortality
Hemilä H.
Vitamin E and Mortality
in Male Smokers of the ATBC Study: Implications for Nutritional
Recommendations.
Frontiers in Nutrition 2020
https://doi.org/10.3389/fnut.2020.00036
https://www.ncbi.nlm.nih.gov/pmc/articles/pmc7136753
In three RCTs
vitamin E decreased the rate of acute kidney injury in participants
going to angiography
Rezaei Y, Hemilä H
Vitamins E and C May
Differ in Their Effect on Contrast-Induced Acute Kidney Injury
American Journal of Kidney Diseases 2017
https://doi.org/10.1053/j.ajkd.2016.12.022
https://www.mv.helsinki.fi/home/hemila/H/2017_L_AJKD.pdf
In Finnish male
smokers, vitamin E
extended life span by half a year
Hemilä H, Kaprio
J.
Vitamin E may affect the life expectancy of men, depending
on dietary vitamin C intake and smoking.
Age Ageing
2011;40:215-220
https://doi.org/10.1093/ageing/afq178
https://www.ncbi.nlm.nih.gov/pubmed/21242192
Very
strong evidence that vitamin E effect on mortality is modified by age
and dietary vitamin C intake (P = 0.0005)
Hemilä H,
Kaprio J.
Modification of the effect of vitamin E
supplementation on the mortality of male smokers by age and dietary
vitamin C.
Am J Epidemiol
2009;169:946-953
https://doi.org/10.1093/aje/kwn413
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661323
https://www.ncbi.nlm.nih.gov/pubmed/19218294
Hemilä H
Comparison of different
vitamin E forms is confounded by heterogeneity in vitamin E effects.
Nutrition Reviews 2018
https://doi.org/10.1093/nutrit/nuy038
Hemilä H.
Vitamin and Mineral Supplements in the Primary
Prevention of Cardiovascular Disease and Cancer.
Ann Intern
Med 2014;160:655.
https://doi.org/10.7326/L14-5009-3
https://www.mv.helsinki.fi/home/hemila/H/2014_L_AIMed.pdf
Hemilä H.
Vitamin E may significantly increase
and decrease mortality in some population groups.
PLoS ONE
[Comment 27 Oct 2013]
https://journals.plos.org/plosone/article/comment?id=info:doi/10.1371/annotation/45d81cb2-2777-447c-b7d4-30236b0f3596
Hemilä
H.
Vitamin supplements and mortality in older people.
AJCN
2013;98:502
https://doi.org/10.3945/ajcn.113.064204
https://www.mv.helsinki.fi/home/hemila/H/2013_L_AJCN.pdf
Hemilä
H.
Vitamin E may extend life span of older males
irrespective of the meta-analysis by Myung et al.
BMJ
[Rapid Response 5 Feb
2013]
https://www.bmj.com/content/346/bmj.f10/rr/629228
Hemilä H.
Antioxidants are not identical and
their effects are not uniform over the population.
[Feedback
on the Cochrane review “Antioxidant supplements for prevention
of mortality in healthy participants and patients with various
diseases” by Bjelakovic G et al.]
Cochrane Database of
Systematic Reviews CD007176 [Feedback 24 August
2009]
https://hdl.handle.net/10138/136201
https://doi.org/10.13140/2.1.4426.0641
Hemilä H.
Vitamin E is likely to
affect mortality even at low doses.
Clinical Trials
2009;6:392-393
https://doi.org/10.1177/1740774509340211
https://helda.helsinki.fi/handle/10138/16982
https://www.mv.helsinki.fi/home/hemila/H/2009_L_ClinTrials_2p.pdf
Hemilä H.
Spectacular reduction in the
mortality of acutely injured patients by the administration of
vitamins C and E and selenium.
JPEN 2009;33:447-448
https://doi.org/10.1177/0148607108328520
https://www.mv.helsinki.fi/home/hemila/H/2009_L_JPEN.pdf
https://hdl.handle.net/10138/16985
Hemilä H.
Antioxidant supplements and
mortality.
JAMA 2007;298:401
https://doi.org/10.1001/jama.298.4.401-a
https://www.mv.helsinki.fi/home/hemila/H/2007_L_JAMA.pdf
Hemilä
H, Miller ER.
Evidence-based medicine and vitamin E
supplementation.
AJCN 2007;86:261-262
https://www.ajcn.org/cgi/content/full/86/1/261
https://www.mv.helsinki.fi/home/hemila/H/2007_L_AJCN.pdf
Hemilä
H.
High-dosage vitamin E supplementation and all-cause
mortality.
Ann Intern Med 2005;143:156-157
https://10.7326/0003-4819-143-2-200507190-00020
https://www.mv.helsinki.fi/home/hemila/H/2005_L_AIMed.pdf