Department
of Public
Health
University of Helsinki,
Finland
harri.hemila@helsinki.fi
https://www.mv.helsinki.fi/home/hemila
Oct
14,
2022
Review on
vitamin C and EIB, and a secondary analysis of a published
study
Hemila
H
The
effect of vitamin C on bronchoconstriction and respiratory symptoms
caused by exercise: a review and statistical analysis.
Allergy,
Asthma & Clinical Immunology
2014;10:58
https://doi.org/10.1186/1710-1492-10-58
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363347
Three
studies found that vitamin C decreased common cold induced asthma
exacerbations or bronchial hypersensitivity.
Hemila
H
Vitamin
C and common
cold-induced asthma: a systematic review and statistical analysis.
Allergy, Asthma Clin Immunol
2013;9:46
https://doi.org/10.1186/1710-1492-9-46
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018579
Three
studies found that vitamin C halved the FEV1 decline caused by
exercise.
Hemila
H
Vitamin
C may
alleviate exercise-induced bronchoconstriction: a meta-analysis.
BMJ Open 2013;3:e002416
https://doi.org/10.1136/bmjopen-2012-002416
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686214
Vitamin
C was reported to alleviate asthma severity in Egyptian children, but
the data set was found to be flawed.
Still
the Egyptian study indicates that the effect of vitamin C should be
further studied,
even though the validity of these particular
findings is not clear.
Hemila
H, Al-Biltagi M, Basset AA
Vitamin
C and asthma in children: modification of the effect by age, exposure
to dampness and the severity of asthma.
Clin
Transl Allergy
2011;1:9
https://doi.org/10.1186/2045-7022-1-9
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339402
Retraction:
https://doi.org/10.1186/2045-7022-2-6
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320558
https://www.ncbi.nlm.nih.gov/pubmed/22423606
Postpublication
problems: reasons for the
retraction:
https://www.mv.helsinki.fi/home/hemila/PPH/CTA/CTA.html
See
also retraction
of the
initial publication on which
the above 2011
subgroup analysis was
based:
https://doi.org/10.1111/j.1651-2227.2012.02723.x
Meta-analysis
of 3 exercise-induced asthma trials and pointing out errors in the
Cochrane review
This was expanded to BMJ Open paper in 2013, see
above
##########################################
Pointing
out errors in the Cochrane review and a meta-analysis of 3
exercise-induced asthma trials
The meta-analysis was expanded to
BMJ Open paper in 2013
The
Cochrane review on vitamin C and asthma misled readers for a decade
from 2001 to 2013
Hemilä
H. Feedback [on the
Cochrane review “vitamin C supplementation for
asthma” (2009) by Kaur B, Rowe BH, Stovold E]
Cochrane Database of Systematic Reviews CD000993 [Feedback 24 March
2009]
https://helda.helsinki.fi/handle/10138/38500
https://doi.org/10.13140/2.1.1280.3364
The above comment was submitted in 2009,
but the authors replied no earlier than in 2012.
Furthermore, the reply was full of
errors:
Hemilä H
Vitamin
C and exercise-induced
bronchoconstriction:
further problems in the Cochrane review
"vitamin C for asthma" (2013).
Unpublished commentary
https://hdl.handle.net/10138/40816
Hemila H. Vitamin
C should be tested against exercise-induced bronchoconstriction.
AJRCCM
2013;188:1370
https://doi.org/10.1164/rccm.201307-1205LE
Hemila
H. Vitamin
C and exercise-induced bronchoconstriction in athletes.
JACI
2009:123:274-275
https://doi.org/10.1016/j.jaci.2008.10.004