EBM, CAM, Placebo

by Harri Hemilš

Department of Public Health
University of Helsinki, Finland
harri.hemila@helsinki.fi
http://www.mv.helsinki.fi/home/hemila   Home page
Oct 1, 2014

  1. EBM and CAM
  2. EBM Problems
  3. Placebo and blinding


EBM and CAM

Louhiala P, Hemilš H. Can CAM treatments be evidence-based?
Focus on Alternative and Complementary Therapies 2014;19(2):84-89
http://dx.doi.org/10.1111/fct.12110

Hemilš H. Alternative Medicine is a Useful Concept.
Medical Humanities [e-Letter Oct 14, 2010]
http://mh.bmj.com/content/36/2/115/reply#1
http://hdl.handle.net/10138/43021

EBM Problems

Hemilš H. Limitations of randomized trials: problems in the “evidence” of EBM
Placebo: Placebo effects in musculoskeletal disorders. [Meeting paper]
13th Physiatric Summer School, 16-17.8.2012, Helsinki
http://www.mv.helsinki.fi/home/hemila/H/HH_2013_Orton.pdf

Placebo and blinding

Papers

Hemilš H.
Vitamin C, the placebo effect, and the common cold:
a case study of how preconceptions influence the analysis of results.
Journal of Clinical Epidemiology 1996;49(10):1079-1084
http://dx.doi.org/10.1016/0895-4356(96)00189-8  
http://hdl.handle.net/10250/8082   Links to references are added
http://www.mv.helsinki.fi/home/hemila/H/HH_1996_JCE.pdf
    Discussion JCE 1996;49:1085-1087
    Chalmers: To the preceding article by H. Hemilš
    http://dx.doi.org/10.1016/0895-4356(96)00190-4
    Hemilš H: Response to the dissent by Thomas Chalmers.
    http://dx.doi.org/10.1016/0895-4356(96)00191-6
    http://hdl.handle.net/10250/8079
    http://www.mv.helsinki.fi/home/hemila/H/HH_1996_JCE2.pdf

Letters and comments

Louhiala P, Hemilš H, Puustinen R.
Clinical use of placebo treatments may undermine the trust of patients: a response to Gold and Lichtenberg.

Journal of Medical Ethics 2014, in press
http://dx.doi.org/10.1136/medethics-2014-102219
http://www.ncbi.nlm.nih.gov/pubmed/24912975

Louhiala P, Puustinen R, Hemilš H.
Impure placebo as an unsound concept and other problems in the paper by Howick et al.

PLoS ONE 2013;8(3):e58247
http://dx.doi.org/10.1371/journal.pone.0058247  (see Comments section)
http://www.plosone.org/annotation/listThread.action?root=64407     (direct link)
http://hdl.handle.net/10138/40220
http://hdl.handle.net/10138/42791
http://hdl.handle.net/10138/42784

Hemilš H. Citation bias in the CONSORT comments on blinding.
BMJ [e-Letter 18 May 2010]
http://dx.doi.org/10.1136/bmj.c869 (see Responses section)
http://www.bmj.com/rapid-response/2011/11/02/citation-bias-consort-comments-blinding   (direct link)
http://hdl.handle.net/10138/43028

Hemilš H. Assessment of the importance of double-blinding should be based on systematic reviews: rebuttal.
Journal of Thrombosis and Haemostasis 2008;6(7):1247-1248
http://dx.doi.org/10.1111/j.1538-7836.2008.03006.x
http://hdl.handle.net/10138/25297 Links to references are added

Hemilš H. RE: “Bias in clinical intervention research”.
American Journal of Epidemiology 2007;165(10):1219
http://dx.doi.org/10.1093/aje/kwm081
    Hemilš H. The author replies [to a commentary on “Bias in clinical intervention research”].
    American Journal of Epidemiology 2008;167(4):501-502
    http://dx.doi.org/10.1093/aje/kwm374
    (Reply to: http://dx.doi.org/10.1093/aje/kwm372)

Hemilš H. Analysis of clinical data with breached blindness.
Statistics in Medicine 2006;25(8):1434-1437
http://dx.doi.org/10.1002/sim.2347
http://www.mv.helsinki.fi/home/hemila/H11.pdf
http://www.mv.helsinki.fi/home/hemila/H/2006_L_SIM.pdf   

Hemilš H. Echinacea, vitamin C, the common cold, and blinding.
Clinical Infectious Diseases 2005;41(5):762-763
http://dx.doi.org/10.1086/432629

Hemilš H. Allocation concealment and blinding: when ignorance is bliss.
Medical Journal of Australia 2005;183(4):165-166
https://www.mja.com.au/journal/2005/183/3/allocation-concealment-and-blinding-when-ignorance-bliss-0
http://www.mv.helsinki.fi/home/hemila/H/2005_L_MJA_2p.pdf  

Hemilš H. Assessment of blinding may be inappropriate after the trial.
Contemporary Clinical Trials 2005;26(4):513-515
http://dx.doi.org/10.1016/j.cct.2005.04.002
http://hdl.handle.net/10250/7981    Links to references are added